|The full article is available to subscribers||Subscriber Login|
Annual vaccination against influenza A and B viruses has been shown to decrease influenza illness and its complications.1
EFFECTIVENESS — The effectiveness of the seasonal vaccine in preventing influenza in healthy adults depends on the match between the vaccine and circulating strains. Vaccine effectiveness is highest (50-80% in young adults; lower in the elderly) when the match is close, but even when the match is poor, vaccination has been shown to reduce the risk of death from influenza.2 In addition, vaccination of children and adolescents can protect unvaccinated residents of the same community.3
Live vs. Inactivated – The intranasal live-attenuated influenza vaccine, FluMist Quadrivalent, is only recommended for healthy, non-pregnant persons 2-49 years old. It appears... more
- LA Grohskopf et al. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP) – United States, 2014-15 influenza season. MMWR Morb Mortal Wkly Rep 2014; 63:691.
- KL Nichol et al. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med 2007; 357:1373.
- M Loeb et al. Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial. JAMA 2010; 303:943.
- RB Belshe et al. Live attenuated virus versus inactivated influenza vaccine in infants and young children. N Engl J Med 2007; 356:685.
- AS Monto et al. Comparative efficacy of inactivated and live attenuated influenza vaccines. N Engl J Med 2009; 361:1260.
- K Goodwin et al. Antibody response to influenza vaccination in the elderly : a quantitative review. Vaccine 2006; 24:1159.
- CA DiazGranados et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med 2014; 371:635.
- JA Udell et al. Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. JAMA 2013; 310:1711.
- MG Thompson et al. Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons. Clin Infect Dis 2014; 58:449.
- SA Madhi et al. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 2014; 371:918.
- JJ Song et al. Long-term immunogenicity of influenza vaccine among the elderly : risk factors for poor immune response and persistence. Vaccine 2010; 28:3929.
- J Castilla et al. Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12. Euro Surveill 2013; 18:pii:20388.
- JC Kwong et al. Risk of Guillain-Barré syndrome after seasonal influenza vaccine and influenza health-care encounters: a self-controlled study. Lancet Infect Dis 2013; 13:769.
- LL Polakowski et al. Chart-confirmed Guillain-Barré syndrome after 2009 H1N1 influenza vaccination among the Medicare population, 2009-2010. Am J Epidemiol 2013; 178:962.