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The pathogenesis of acne is multifactorial: follicular hyperkeratinization, bacteria, sebum production, androgens, and inflammation all play a role. The gram-positive microaerophilic bacteria Propionibacterium acnes promotes development of acne lesions by secreting chemotactic factors that attract leukocytes to the follicle, causing inflammation.
TOPICAL THERAPY — Salicylic Acid – Widely available over the counter (OTC), topical salicylic acid is a well-tolerated keratolytic agent that can be used alone or in combination with other drugs such as benzoyl peroxide.
Benzoyl Peroxide – The oxidizing agent benzoyl peroxide is available in a wide variety of OTC and prescription preparations for treatment of mild to moderate acne. Its effect is primarily due to its antibacterial activity against P. acnes. Benzoyl peroxide is often used in combination with topical or oral antibiotics. It... more
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