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With the widespread adoption of the CHA2DS2-VASc scoring system,1 oral anticoagulation therapy is now recommended for all patients ≥75 years old with nonvalvular atrial fibrillation.2,3 Atrial fibrillation has, however, been associated with an increased risk of falls, and older patients starting warfarin for atrial fibrillation have a high rate of hospitalization for intracranial bleeding.4,5 Many practitioners are reluctant, therefore, to prescribe an oral anticoagulant for elderly patients who are at high risk for falls.
Most data on this subject come from patients who were treated with warfarin. The newer direct oral anticoagulants dabigatran etexilate (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa) have been shown to be at least as... more
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