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Topical Penciclovir for Herpes Labialis

Penciclovir 1% cream (Denavir - SmithKline Beecham) has been approved by the US Food and Drug Administration (FDA) for treatment of recurrent orolabial herpes simplex virus (HSV) infections in adults. Acyclovir (Zovirax) is also available in a topical formulation for treatment of herpes simplex infections, but is approved by the FDA only for use in immunocompromised patients. Oral drugs approved for treatment of some herpes simplex infections, but not recurrent orolabial infections, include acyclovir, valacyclovir (Valtrex) and famciclovir (Famvir), which is rapidly hydrolyzed to penciclovir in vivo (Medical Letter, 36:97, 1994)....
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Information about the article:
Title: Topical Penciclovir for Herpes Labialis
Publication: The Medical Letter on Drugs and Therapeutics
Issue #: 1003
Article Code: 1003a
Date: June 20, 1997
Volume: 39
Pages: 57-58

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