Serious adverse interactions between drugs continue to be reported. Many of these are due to inhibition or induction of cytochrome P450 (CYP) enzymes, particularly CYP3A4. CYP3A is thought to be involved in the metabolism of more than 50 percent of currently prescribed drugs.2 CYP3A4, which is more abundantly expressed than CYP3A5, accounts for most CYP3A activity in vivo....
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Information about the article:
Title: CYP3A and Drug Interactions
Publication: The Medical Letter on Drugs and Therapeutics
Issue #: 1212
Article Code: 1212b
Date: July 4, 2005
Volume: 47
Pages: 54-55