The Medical Letter on Drugs and Therapeutics
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1179
Palonosetron (Aloxi) for Prevention of Nausea and Vomiting Due to Cancer Chemotherapy
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Palonosetron (Aloxi - Helsinn Healthcare SA, Switzerland, distributed in the US by MGI Pharma) is the fourth serotonin (5-HT3) receptor antagonist to become available in the US and the first to be approved by the FDA for prevention of both acute and delayed nausea and vomiting due to moderately emetogenic cancer chemotherapy. It is also approved for prevention of acute nausea and vomiting due to highly emetogenic drugs such as cisplatin (Platinol, and others). Aprepitant (Emend), a substance P/neurokinin-1 receptor antagonist, was approved last year for use with a 5-HT3 antagonist and dexamethasone to prevent both acute and delayed nausea and vomiting due to highly emetogenic drugs (Medical Letter 2003; 45:62). ... more
     
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Title: Palonosetron (Aloxi) for Prevention of Nausea and Vomiting Due to Cancer Chemotherapy
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