The Medical Letter on Drugs and Therapeutics
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1232
Lenalidomide (Revlimid) for Anemia of Myelodysplastic Syndrome
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Lenalidomide (Revlimid – Celgene), a thalidomide analog, has been approved by the FDA for treatment of patients with transfusion-dependent anemia due to myelodysplastic syndrome (MDS) associated with a 5q deletion cytogenetic abnormality and a low or low-intermediate risk of mortality and progression to leukemia (based on the International Prognostic Scoring System).1

5q DELETION AND MDS — MDS is a heterogeneous group of malignant bone marrow disorders with a high incidence of cytogenetic abnormalities. Patients with MDS often present with cytopenias, and some progress to acute leukemia. A 5q deletion can occur in up to 30% of patients with MDS; when it is the only cytogenetic abnormality, it is associated with a more favorable prognosis.1 Azacitidine (Vidaza), a pyrimidine analog used to treat MDS, was reviewed in an earlier ... more      

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Title: Lenalidomide (Revlimid) for Anemia of Myelodysplastic Syndrome
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