The Medical Letter on Drugs and Therapeutics
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1255
Two New Drugs for Renal Cell Carcinoma
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Revised 2/22/07: Corrected reference number in Dosage and Cost section.

Sunitinib (Sutent – Pfizer) and sorafenib (Nexavar – Bayer), two oral tyrosine kinase inhibitors, have been approved by the FDA for treatment of advanced renal cell carcinoma (RCC). Sunitinib is also approved for use in patients with gastrointestinal stromal tumor (GIST) who are not responding to or are intolerant of standard therapy with imatinib (Gleevec).

DRUGS FOR ADVANCED RCC — The cytokines interleukin- 2 (IL-2) and interferon alfa have been used to treat advanced RCC. Interferon alfa has produced a response rate of 14% with a median duration of 6 months. High-dose IL-2 has produced a response rate of 21%, with substantial toxicity (capillary leak syndrome), but with a median duration of 54 months.1

SUNITINIB — Mechanism of Action – Sunitinib inhibits a variety of transmembrane receptor tyrosine kinases including vascular endothelial ... more      

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