The Medical Letter on Drugs and Therapeutics
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1265
Lisdexamfetamine dimesylate (Vyvanse) for ADHD
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Lisdexamfetamine dimesylate (Vyvanse – Shire), a prodrug in which d-amphetamine is covalently bonded to L-lysine, has been approved by the FDA for treatment of attention-deficit/hyperactivity disorder (ADHD) in children 6-12 years old. It was designed to have less potential than amphetamine itself for abuse, diversion or overdose toxicity.1,2 Like methylphenidate and amphetamines, lisdexamfetamine is a Schedule II controlled substance.

PHARMACOKINETICS — Lisdexamfetamine dimesylate is converted to d-amphetamine and L-lysine by enzymatic hydrolysis. Peak plasma concentrations of d-amphetamine after a 50-mg oral dose of lisdexamfetamine are about the same as those after a 30-mg oral dose of immediate-release d-amphetamine. Only minimal amounts of d-amphetamine are released when the drug is administered parenterally.

CLINICAL STUDIES — A randomized clinical trial ... more      

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Title: Lisdexamfetamine dimesylate (Vyvanse) for ADHD
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