The Medical Letter on Drugs and Therapeutics
Pregabalin (Lyrica) for Fibromyalgia
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Pregabalin (Lyrica – Pfizer) is the first drug approved by the FDA for management of fibromyalgia. When it was first marketed, pregabalin, which is structurally similar to gabapentin (Neurontin, and others), was approved for treatment of neuropathic pain associated with postherpetic neuralgia and diabetic peripheral neuropathy and for adjunctive treatment of partial onset seizures in adults with epilepsy.1 It has also been prescribed off-label for other types of neuropathic pain such as sciatica.

FIBROMYALGIA — A chronic disorder mainly affecting women, fibromyalgia is characterized by pain, fatigue and sleep problems. It has been treated with many different drugs, including analgesics, muscle relaxants, anticonvulsants such as gabapentin, and antidepressants; the tricyclic antidepressant amitriptyline (Elavil, and others) has probably been the best studied. ... more      

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Title: Pregabalin (Lyrica) for Fibromyalgia
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