Treatment Guidelines from The Medical Letter
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127
Antiviral Drugs
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Revised 2/6/15: A sentence about the discontinuation of boceprevir and telaprevir has been added to that paragraph, and to footnote 7 in Table 5.

The drugs of choice for treatment of viral infections (other than HIV) and their dosages are listed in Tables 1-6 on the pages that follow. Some of the indications and dosages recommended here have not been approved by the FDA. Vaccines used for the prevention of viral infections are discussed elsewhere.1

VARICELLA-ZOSTER AND HERPES SIMPLEX VIRUS

ACYCLOVIR — Available in topical, oral and IV formulations, acyclovir (Zovirax, and generics) is used to treat and suppress varicella-zoster virus (VZV) and herpes simplex virus (HSV) infections.

Oral acyclovir begun within 24 hours of rash onset decreases the severity of primary VZV infection (chicken pox). It can also reduce pain and the risk of post-herpetic neuralgia in patients with localized zoster if taken within 48-72 hours after the onset of rash. Suppression with oral acyclovir ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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