The Medical Letter on Drugs and Therapeutics
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Simcor: A Niacin/Simvastatin Combination

The FDA has approved the marketing of a second fixed-dose combination of extended-release niacin (Niaspan) with a generic statin. Niaspan/simvastatin (Simcor – Abbott) is approved for use in patients with hypercholesterolemia or mixed dyslipidemia (high LDL-cholesterol, low HDL-cholesterol and high serum triglycerides). Niaspan/lovastatin (Advicor) was marketed previously for the same indications.1

STATINS — Statins are more effective than other drugs in lowering LDL-C, and they also lower triglycerides. Most statins increase HDL-C only modestly. Statins have dose-related differences in how much they lower LDL-C. A lovastatin dose of 20 mg usually lowers LDL-C by 25%-30%; a maximum dose of 80 mg lowers it by 35%-40%. A simvastatin dose of 20 mg lowers LDL-C by 35%-40%; a maximum dose of 80 mg lowers it by 45%-50%.2

NIACIN — ... more      

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