The Medical Letter on Drugs and Therapeutics
Nilotinib (Tasigna) for CML
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Nilotinib (Tasigna – Novartis), a tyrosine kinase inhibitor, has been approved by the FDA for treatment of Philadelphia chromosome-positive (Ph+) chronic or accelerated phase chronic myelogenous leukemia (CML) in patients resistant to or intolerant of imatinib (Gleevec).

STANDARD TREATMENT — Imatinib, the first tyrosine kinase inhibitor for treatment of CML, was approved by the FDA in 2001.1 It is now the standard first-line treatment for all phases of Ph+ CML. Primary treatment of chronic phase CML with imatinib results in a complete cytogenetic response rate of 87% and an overall survival rate of 89% at 5 years.2 Patients who do not respond to imatinib may be treated with higher doses of imatinib, another tyrosine kinase inhibitor, or allogeneic stem-cell transplantation. Dasatinib (Sprycel), the second tyrosine kinase inhibitor for treatment of CML, ... more      

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Title: Nilotinib (Tasigna) for CML
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