The Medical Letter on Drugs and Therapeutics
A Fixed-Dose Combination of Sumatriptan and Naproxen for Migraine
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The FDA has approved an oral, fixed-dose combination (Treximet – GlaxoSmithKline) of the selective serotonin receptor agonist (“triptan”) sumatriptan (Imitrex) and the nonsteroidal anti-inflammatory drug (NSAID) naproxen sodium (Anaprox, and others) for acute treatment of migraine attacks. Imitrex tablets are expected to go off-patent in February 2009.

STANDARD TREATMENT — Mild or moderate episodes of migraine are often treated with nonopioid analgesics such as aspirin or acetaminophen, used alone or in combination with caffeine, butalbital and other drugs. A combination of aspirin, acetaminophen and caffeine (Excedrin Migraine) is available over the counter (OTC). The NSAID ibuprofen in a dose of 200 mg (Advil, and others) is FDA-approved for OTC treatment of migraine, and other NSAIDs, including naproxen, have been used as well.

For moderate to severe ... more      

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