The Medical Letter on Drugs and Therapeutics
Antiplatelet Therapy for Patients with Stents
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The antiplatelet agents aspirin and clopidogrel (Plavix, and others)1 are used in most patients undergoing percutaneous coronary intervention (PCI) to prevent stent thrombosis and to reduce the occurrence of peri-, post-procedural and late cardiovascular events. Despite a large number of randomized trials of these agents in such patients, the optimal dosage and duration of treatment with these drugs, and whether other drugs should be added, is unclear.

BEFORE PCI — Aspirin – The minimal effective dose of aspirin has not been established. The present recommendation in the American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines is to give 75-325 mg of aspirin (81 mg is the lowest dose available in the US) before PCI to patients on chronic aspirin therapy and 300-325 mg of aspirin to patients not on chronic aspirin therapy a minimum of 2 hours before ... more      

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Title: Antiplatelet Therapy for Patients with Stents
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