The Medical Letter on Drugs and Therapeutics
A Granisetron Patch (Sancuso)
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The treatment of choice to prevent emesis due to highand moderate-risk emetogenic drugs used in cancer chemotherapy is aprepitant1 plus a serotonin receptor antagonist plus dexamethasone. Four serotonin receptor antagonists are available in the US in intravenous (IV) formulations for prevention of nausea and vomiting due to cancer chemotherapy, and 3 of these are also available for oral use. Now the FDA has approved one of these, granisetron, in a transdermal formulation (Sancuso – ProStrakan).

PHARMACOKINETICS — According to the manufacturer, the new patch releases 3.1 mg of granisetron by passive diffusion every 24 hours for up to 7 days. Granisetron serum concentrations peak about 48 hours after the patch is applied to the skin. The drug is metabolized in the liver, partly by CYP3A4, and excreted in urine and in feces.

CLINICAL STUDIES — An unpublished ... more      

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Title: A Granisetron Patch (Sancuso)
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