The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1329
Telavancin (Vibativ) for Gram-Positive Skin Infections
The full article is available to subscribers Subscriber Login   

Telavancin (Vibativ– Astellas and Theravance), a lipoglycopeptide derivative of vancomycin (Vancocin, and others), has received FDA approval for treatment of complicated skin and skin structure infections caused by susceptible gram-positive bacteria in adults.

MECHANISM OF ACTION — Telavancin inhibits bacterial cell wall synthesis and disrupts bacterial cell membrane function.

ACTIVITYIn vitro, telavancin is bactericidal against Staphylococcus aureus (including methicillin-resistant strains [MRSA]), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae (including penicillin-resistant isolates), Streptococcus angiosus group, and Enterococcus faecalis (vancomycin-susceptible isolates only).

Medical Letter consultants believe telavancin will prove to have no useful activity against ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Telavancin (Vibativ) for Gram-Positive Skin Infections
Article code: 1329a
 Electronic, downloadable article - $25