The Medical Letter on Drugs and Therapeutics
Fentanyl Buccal Soluble Film (Onsolis) for Breakthrough Cancer Pain
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Fentanyl buccal soluble film (Onsolis – Meda) has been approved by the FDA for treatment of breakthrough pain in adult cancer patients who are already taking and are tolerant to around-the-clock opioid therapy. It is designated as a Schedule II controlled substanceTwo other oral transmucosal formulations of fentanyl are already available for this indication.1,2

ADMINISTRATIONOnsolis uses a drug delivery technology called BioErodible MucoAdhesive (BEMA). It is packaged as a dime- or nickel-sized film with a white side that identifies the dosage strength, and a pink side that contains the active ingredient. The pink side is placed against the inside of the moistened cheek, held for 5 seconds and then left in place. The patient can drink liquids after 5 minutes, but should avoid food until the film dissolves (usually 15-30 minutes). Tearing, chewing or swallowing the film can ... more      

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Title: Fentanyl Buccal Soluble Film (Onsolis) for Breakthrough Cancer Pain
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