The Medical Letter on Drugs and Therapeutics
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Bromocriptine (Cycloset) for Type 2 Diabetes

The FDA has approved a new tablet formulation of bromocriptine mesylate (Cycloset – VeroScience) for treatment of type 2 diabetes in adults. Bromocriptine (Parlodel, and others) is an ergot-derived dopamine agonist that has been used for more than 20 years to treat hyperprolactinemia, acromegaly, Parkinson’s disease and restless leg syndrome.

MECHANISM OF ACTION — The mechanism of action of bromocriptine in treating diabetes is unknown. It is thought to involve increased dopaminergic activity in the hypothalamus.1 Bromocriptine decreases postprandial serum glucose concentrations without increasing serum insulin concentrations. In some animal studies, bromocriptine given early in the day prevented the development of insulin resistance and decreased endogenous glucose production.

PHARMACOKINETICS — The new tablet formulation of bromocriptine is 65-95% ... more      

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