The Medical Letter on Drugs and Therapeutics
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Lurasidone (Latuda) for Schizophrenia

The FDA has approved lurasidone (Latuda – Sunovion), a new second-generation antipsychotic, for oral treatment of schizophrenia in adults.

DRUGS FOR SCHIZOPHRENIA — Controlled trials have failed to demonstrate greater efficacy with the second-generation antipsychotics shown in Table 2 compared to less expensive first-generation drugs such as haloperidol (Haldol, and others), except for clozapine, which requires monitoring to prevent life-threatening adverse effects, and possibly olanzapine, which has substantial adverse metabolic effects.1 The second-generation antipsychotics do have a relatively low risk of extrapyramidal symptoms, and are probably less likely than first-generation antipsychotics to cause tardive dyskinesia.2

CLINICAL STUDIES — Four 6-week, fixed-dose placebo-controlled trials ... more      

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