The Medical Letter on Drugs and Therapeutics
A New Testosterone Gel (Fortesta) for Hypogonadism
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.
Revised 5/16/11: In Table 1, the price of a 5-mL (200 mg/mL) vial of testosterone enanthate should have been $79.30 for the generic and $91.30 for the brand (Delatestryl), not $15.86 (generic) and $18.26 (brand).

The FDA has approved Fortesta (Endo), a topical gel, for testosterone replacement therapy in adult males with hypogonadism. It is classified as a Schedule III controlled substance. Table 1 lists some available testosterone products, including 2 other gels.

HYPOGONADISM — Failure of the testes to produce adequate amounts of testosterone can lead to loss of energy, decreased libido, erectile dysfunction, decreased axillary and pubic hair, loss of muscle mass, anemia and osteoporosis.1 Testosterone serum concentrations are difficult to measure and may require 2 or more determinations. Levels decrease with age, falling by about 1-2% per year after the age of 40.2 The normal range (usually ≥300 ng/dL) is based on serum concentrations in young men. Older men with signs and symptoms of hypogonadism may have levels ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: A New Testosterone Gel (Fortesta) for Hypogonadism
Article code: 1362b
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian