The Medical Letter on Drugs and Therapeutics
Eribulin Mesylate (Halaven) for Breast Cancer
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Eribulin mesylate (Halaven – Eisai) has been approved by the FDA for treatment of patients with metastatic breast cancer who have previously received at least 2 chemotherapy regimens for metastatic cancer. Prior therapy should have included an anthracycline and a taxane in either an adjuvant or metastatic setting. Other drugs used to treat anthracycline- and taxane-refractory metastatic breast cancer include capecitabine (Xeloda), gemcitabine (Gemzar, and others) and vinorelbine (Navelbine, and others).1

MECHANISM OF ACTION — Eribulin is an analog of halichondrin B, a macrolide found in marine sponges that has marked anticancer activity. It suppresses microtubule polymerization and sequesters tubulin into nonfunctional aggregates.2

CLINICAL STUDIES — Approval of eribulin was ... more      

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Title: Eribulin Mesylate (Halaven) for Breast Cancer
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