Progesterone for Prevention of Premature Birth
Progesterone for Prevention of Premature Birth
May 16, 2011 (Issue: 1364)
The FDA recently approved the marketing of
hydroxyprogesterone caproate injection (Makena –
Ther-Rx) for prevention of preterm birth in women
with a singleton pregnancy who have a history of singleton
spontaneous preterm birth.
1. T Zakar and S Mesiano. How does progesterone relax the uterus in pregnancy? N Engl J Med 2011; 364:972.
2. PJ Meis et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 2003; 348:2379.
3. P Majhi et al. Intravaginal use of natural micronised progesterone to prevent pre-term birth: a randomized trial in India. J Obstet Gynaecol 2009; 29:493.
4. JM O’ Brien et al. Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2007; 30:687.
5. EA DeFranco et al. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2007; 30:697.
6. EB Fonseca et al. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 2007; 357:462.
7. SS Hassan et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2011; April 6 (epub).
8. DJ Rouse et al. A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. N Engl J Med 2007; 357:454.
9. JE Norman et al. Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomized, double-blind, placebo-controlled study and meta-analysis. Lancet 2009; 373:2034.
10. Food and Drug Administration. FDA Statement on Makena. Available at www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm249025.htm. Accessed May 9, 2011.
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