The Medical Letter on Drugs and Therapeutics
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Vilazodone (Viibryd) - A New Antidepressant

Vilazodone (Viibryd – Forest), a selective serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist, has been approved by the FDA for treatment of depression. It has been claimed to have no sexual side effects and not to cause weight gain.

RATIONALE — The manufacturer’s premise is that addition of an agonist at 5-HT1A could possibly lead to an earlier antidepressant effect and a decrease in SSRI-induced sexual side effects.1 Buspirone (Buspar, and others), a 5-HT1A agonist used for treatment of anxiety, has been tried as an add-on to an SSRI in patients not responding adequately to SSRI monotherapy.2

PHARMACOLOGY — Vilazodone peak serum concentrations are higher and the area under the concentration- time curve (AUC) is greater (64-85%) when the drug is ... more      

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