The Medical Letter on Drugs and Therapeutics
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1368
Testosterone Topical Solution (Axiron) for Hypogonadism
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The Medical Letter recently reviewed a topical gel formulation of testosterone (Fortesta) for treatment of hypogonadism in men.1 A topical testosterone replacement product for application to the axilla, Axiron (Lilly) solution, has now become available for the same indication. This site of application presumably minimizes the risk of transferring the drug to a family member or sexual partner.

PHARMACOKINETICS — Steady state concentrations of testosterone are reached after about 14 days of administration of Axiron and return to pretreatment levels 7-10 days after the last application.

CLINICAL STUDY — In an unpublished 120-day open-label trial summarized in the package insert, 155 hypogonadal men (19-78 years old; median age 53) applied Axiron to the axillary area, starting with a 60-mg dose; the dose could be adjusted ... more      

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Title: Testosterone Topical Solution (Axiron) for Hypogonadism
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