The Medical Letter on Drugs and Therapeutics
Misoprostol for Miscarriage
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Misoprostol (Cytotec, and generics), a prostaglandin E1 analog FDA-approved for prevention of NSAID-induced gastric ulcers1 and, when taken with mifepristone (Mifeprex), for termination of early intrauterine pregnancy,2 has also been used off-label for years for medical management of first-trimester spontaneous abortion (miscarriage).

SPONTANEOUS ABORTION — Miscarriage occurs in about 10-15% of pregnancies.3 For women with an incomplete or missed first-trimester miscarriage documented by an ultrasound, the gestational sac can be removed by suction curettage or medical treatment with misoprostol. Some women, given a choice, elect expectant management rather than surgical or medical intervention; in one study, 70% of untreated women completed their miscarriage within 14 days ... more      

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Title: Misoprostol for Miscarriage
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