The Medical Letter on Drugs and Therapeutics
Dimethyl Fumarate (Tecfidera) for Multiple Sclerosis
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The FDA has approved dimethyl fumarate (Tecfidera – Biogen Idec), formerly called BG-12, for treatment of relapsing forms of multiple sclerosis (MS). It is the third oral drug to be approved in recent years for this indication.1

STANDARD TREATMENT — Interferon beta and glatiramer acetate are commonly used for first-line treatment of MS. Natalizumab and mitoxantrone are second-line parenteral drugs that have severe adverse effects. Oral drugs have only been available since 2010 and have generally been used as second-line agents.

MECHANISM OF ACTION — The mechanism of action of dimethyl fumarate in MS has not been established. It has been shown to activate an antioxidant response pathway (Nrf2) thought to be the primary cellular defense against oxidative stress.2

CLINICAL STUDIES — ... more      

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Title: Dimethyl Fumarate (Tecfidera) for Multiple Sclerosis
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