The Medical Letter on Drugs and Therapeutics
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1420
Quartette: An Ascending-Dose, Extended-Cycle Oral Contraceptive
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The FDA has approved Quartette (Teva), an extended-cycle combination oral contraceptive containing increasing doses of the estrogen ethinyl estradiol (EE) combined with the progestin levonorgestrel (LNG). The rationale is that a gradual increase in the EE dose may reduce unscheduled bleeding or spotting, a common adverse effect of extended-cycle oral contraceptives.1

CLINICAL STUDIES — In an unpublished open-label, single-arm study, 3565 women were treated with Quartette for up to 1 year (4 cycles). The pregnancy rate (Pearl Index) among women 18-35 years old, based on 70 on-treatment pregnancies, was 3.19 per 100 woman-years of use.2

An unpublished study, available only as an abstract, combined data from several clinical studies of extended-cycle combination oral contraceptives to compare the incidence of unscheduled ... more      

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Title: Quartette: An Ascending-Dose, Extended-Cycle Oral Contraceptive
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