The Medical Letter on Drugs and Therapeutics
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1422
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Diclegis for Nausea and Vomiting of Pregnancy

The FDA has approved Diclegis (Duchesnay), a fixed-dose, delayed-release combination of the H1-antihistamine doxylamine and the vitamin B6 analog pyridoxine, for treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. It is only available by prescription. Doxylamine and pyridoxine, both currently available over the counter, were previously available by prescription in a fixed-dose combination (Bendectin) for morning sickness. Bendectin was voluntarily withdrawn in the US in 1983 because of claims of teratogenicity that have since been disproven. The combination has continued to be available in Canada as Diclectin.

STANDARD TREATMENT — Women with nausea and vomiting of pregnancy are generally advised to rest, avoid nauseating stimuli, and eat small, frequent meals low in fat and spices. ... more      

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