The Medical Letter on Drugs and Therapeutics
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Breo Ellipta: An Inhaled Fluticasone/Vilanterol Combination for COPD

The FDA has approved an inhaled fixed-dose combination (Breo Ellipta – GSK/Theravance) of the corticosteroid fluticasone furoate and the long-acting beta2-adrenergic agonist (LABA) vilanterol trifenatate for once-daily treatment of chronic obstructive pulmonary disease (COPD).

This is the first approved indication for vilanterol. Fluticasone furoate is also approved as a nasal spray for treatment of allergic rhinitis. Fluticasone propionate is available alone for treatment of asthma and in combination with salmeterol for treatment of COPD and asthma. Breo Ellipta has not been approved for use in asthma.

MAINTENANCE TREATMENT OF COPD — For patients with moderate to severe airflow obstruction and chronic symptoms, regular treatment with an inhaled long-acting bronchodilator (a LABA or an anticholinergic) can relieve symptoms, improve lung function, decrease the frequency of exacerbations, ... more      

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