The Medical Letter on Drugs and Therapeutics
Ado-Trastuzumab Emtansine (Kadcyla) for HER2-Positive Metastatic Breast Cancer
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Ado-trastuzumab emtansine (Kadcyla – Genentech), a human epidermal growth factor receptor 2 (HER2)-targeted antibody and microtubule inhibitor conjugate, has been approved by the FDA for intravenous (IV) treatment of HER2-positive metastatic breast cancer in patients previously treated with trastuzumab (Herceptin) and a taxane. The prefix was added to the new conjugate’s name at the request of the FDA to distinguish it from trastuzumab.

MECHANISM OF ACTION — HER2, a transmembrane receptor protein involved in normal cell growth, is overexpressed in about 15-20% of breast cancers.1,2 Amplification of HER2 is associated with more aggressive disease and reduced survival.3 Adotrastuzumab emtansine binds to the HER2 receptor, is internalized, and undergoes lysosomal degradation to trastuzumab and the microtubule inhibitor ... more      

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Title: Ado-Trastuzumab Emtansine (Kadcyla) for HER2-Positive Metastatic Breast Cancer
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