ISSUE 1427
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Deep brain stimulation is FDA-approved and has been used for years to treat patients with advanced Parkinson's disease (PD) who have severe levodopa-induced motor complications.1 New evidence from a controlled trial suggests that it may also be effective for patients with PD and early motor complications.
SURGICAL TREATMENT — Medical therapy is effective for initial treatment of PD.2 Surgical ablation or deep brain stimulation has generally been recommended only for patients with intolerable dyskinesias or motor fluctuations while on levodopa. Appropriate candidates for surgery are those whose cognition is relatively intact, who are not depressed, and who have no medical contraindications.3
DEEP BRAIN STIMULATION — High-frequency electrical stimulation of the subthalamic nucleus or
... more1. Deep brain stimulation for Parkinson's disease. Med Lett Drugs Ther 2009; 51.26.
2. Drugs for Parkinson's disease. Treat Guidel Med Lett 2013; in press.
3. J Jankovic and W Poewe. Therapies in Parkinson's disease. Curr Opin Neurol 2012; 25:433.
4. MS Okun. Deep-brain stimulation for Parkinson's disease. N Engl J Med 2012; 367:1529.
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