The Medical Letter on Drugs and Therapeutics
Vortioxetine (Brintellix/Trintellix) for Depression
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Revised 5/10/16: In May 2016, the brand name of vortioxetine was changed from Brintellix to Trintellix.

The FDA has approved vortioxetine (vor" tye ox' e teen; Brintellix/Trintellix – Takeda/Lundbeck), a new serotonergic drug, for treatment of major depressive disorder. Like vilazodone (Viibryd)1, another serotonergic antidepressant, it has been claimed to have a low incidence of sexual side effects and no significant effect on weight.

MECHANISM OF ACTION — Vortioxetine has multiple effects on serotonin neurotransmission. It selectively inhibits reuptake of serotonin and acts as an agonist or antagonist at various serotonin receptors. The clinical significance of these activities, other than serotonin reuptake inhibition, have not been established, but the manufacturer describes vortioxetine as a multimodal antidepressant.

CLINICAL STUDIES — Three unpublished 8-week trials (summarized in the package insert) found vortioxetine 20 ... more      

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Title: Vortioxetine (Brintellix Trintellix) for Depression
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