The Medical Letter on Drugs and Therapeutics
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1439
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Golimumab (Simponi) for Ulcerative Colitis

The FDA has approved golimumab (Simponi – Janssen), a fully human monoclonal antibody specific for tumor necrosis factor (TNF) alpha, for induction and maintenance of remission in patients with moderate to severe ulcerative colitis who do not respond to or cannot tolerate other therapies or who require continuous treatment with corticosteroids. Golimumab was approved earlier for treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.1 It is the third TNF inhibitor to be approved for use in ulcerative colitis.2

TREATMENT OF ULCERATIVE COLITIS — For mild to moderate ulcerative colitis, an aminosalicylate such as mesalamine is generally the first drug tried for induction and maintenance of remission. Oral prednisone is effective for inducing remission in patients who do not respond to an aminosalicylate or ... more      

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