The Medical Letter on Drugs and Therapeutics
Sorafenib (Nexavar) for Thyroid Cancer
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The FDA has approved the use of the oral multikinase inhibitor sorafenib (Nexavar – Bayer) for treatment of locally recurrent or metastatic, progressive, differentiated thyroid cancer (papillary or follicular) refractory to radioactive iodine treatment. Sorafenib was approved earlier for treatment of advanced renal cell and unresectable hepatocellular cancer.1

STANDARD TREATMENT — Surgery and radioactive iodine are the preferred treatments for thyroid cancer. When these fail, cytotoxic drugs have not been very effective and kinase inhibitors including sorafenib have been used. Two other kinase inhibitors, vandetanib (Caprelsa) and cabozantinib (Cometriq), were approved earlier for treatment of advanced medullary thyroid cancer, which is relatively rare.2

CLINICAL STUDIES — A meta-analysis of ... more      

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Title: Sorafenib (Nexavar) for Thyroid Cancer
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