The Medical Letter on Drugs and Therapeutics
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Low-Dose Aspirin for Prevention of Preeclampsia

The American College of Obstetricians and Gynecologists (ACOG) and the US Preventive Services Task Force (USPSTF) have recommended that women at risk for preeclampsia take low-dose aspirin daily after the first trimester.1,2

PREECLAMPSIA — Preeclampsia is a multisystem disorder characterized by hypertension and proteinuria that occurs after 20 weeks' gestation and can result in significant maternal and fetal morbidity and mortality. In severe cases, the mother may have severe headache, visual disturbances, thrombocytopenia, renal insufficiency, and impaired liver function, with an increased risk of seizures (eclampsia), pulmonary edema, stroke, and death. In the fetus, preeclampsia can cause intrauterine growth restriction, premature delivery, and death. Delivery is the only definitive treatment.

A NEW REVIEW — An analysis of 21 randomized controlled trials and ... more      

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