The Medical Letter on Drugs and Therapeutics
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1447
Ceritinib (Zykadia) for Non-Small Cell Lung Cancer
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Ceritinib (Zykadia – Novartis), an oral tyrosine kinase inhibitor, has received accelerated approval from the FDA for treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib (Xalkori). It is the second tyrosine kinase inhibitor to be approved for ALK-positive metastatic NSCLC; crizotinib was the first.1 Translocations of the ALK gene are found in about 5% of lung cancers2; they occur predominantly in nonsmokers with adenocarcinoma.

MECHANISM OF ACTION — Translocations of ALK, a receptor tyrosine kinase, result in expression of oncogenic fusion proteins, which increase cell proliferation. Ceritinib inhibits ALK and other receptor tyrosine kinases.

CLINICAL STUDIES — A ... more      

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