The Medical Letter on Drugs and Therapeutics
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1449
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Two New Drugs for Skin and Skin Structure Infections

The FDA has approved two new drugs for treatment of adults with acute bacterial skin and skin structure infections caused by susceptible gram-positive bacteria. Dalbavancin (Dalvance – Durata) is a long-acting intravenous (IV) lipoglycopeptide antibiotic similar to telavancin (Vibativ).1 Tedizolid phosphate (Sivextro – Cubist) is an IV and oral oxazolidinone antibacterial drug similar to linezolid (Zyvox).2 A third IV antibiotic, oritavancin (Orbactiv), recently approved by the FDA for the same indication, will be reviewed in a future issue.

STANDARD TREATMENT — Patients hospitalized for non-purulent skin and soft-tissue infections, which are often caused by streptococci, can usually be treated empirically with IV penicillin, cefazolin, ceftriaxone, or ... more      

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