The Medical Letter on Drugs and Therapeutics
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1449
Sucroferric Oxyhydroxide (Velphoro) for Hyperphosphatemia
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Most patients with end-stage renal disease develop hyperphosphatemia, which can lead to secondary hyperparathyroidism, vascular calcification, and cardiovascular mortality. The FDA has approved sucroferric oxyhydroxide (Velphoro – Fresenius Medical Care), a chewable phosphate binder, for treatment of hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis. It is the first iron-based phosphate binder to be approved for this indication.

STANDARD TREATMENT — Dietary restriction of phosphate and dialysis treatment are somewhat effective in lowering serum phosphorus levels, but addition of an oral phosphate binder is often needed. Whether phosphate-binding drugs can improve clinical outcomes has not been established.

The anion-exchange resin sevelamer carbonate (Renvela)1 and the calcium-based phosphate binder calcium acetate (PhosLo, ... more      

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Title: Sucroferric Oxyhydroxide (Velphoro) for Hyperphosphatemia
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