The Medical Letter on Drugs and Therapeutics
Obinutuzumab (Gazyva) for Chronic Lymphocytic Leukemia (online only)
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Obinutuzumab (Gazyva – Genentech), a humanized anti-CD20 monoclonal antibody, has been approved by the FDA for use in combination with chlorambucil (Leukeran) in patients with previously untreated chronic lymphocytic leukemia (CLL). Two other anti-CD20 antibodies, rituximab (Rituxan) and ofatumumab (Arzerra),1 were previously approved for treatment of CLL.

STANDARD TREATMENT — Initial treatment of advanced or symptomatic CLL usually includes fludarabine, rituximab, and cyclophosphamide (Cytoxan, and others).2 Combining rituximab or ofatumumab with the alkylating agent chlorambucil has been effective in elderly patients and in those with coexisting medical conditions, who often have difficulty tolerating chemotherapy.

Ibrutinib (Imbruvica), an oral inhibitor of Bruton's tyrosine ... more      

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Title: Obinutuzumab (Gazyva) for Chronic Lymphocytic Leukemia (online only)
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