The Medical Letter on Drugs and Therapeutics
Extended-Release Hydrocodone (Hysingla ER) for Pain
The full article is available to subscribers Subscriber Login   

The FDA has approved a second extended-release (ER) formulation of the oral opioid agonist hydrocodone (Hysingla ER – Purdue) for management of pain severe enough to require continuous long-term therapy and for which alternative treatment options are inadequate. Hysingla ER tablets have abuse-deterrent properties to discourage their misuse.

HYDROCODONE — Hydrocodone has been available for years in combination with acetaminophen (Vicodin, and others) or ibuprofen (Vicoprofen, and others). The first single-ingredient hydrocodone product to be marketed in the US was Zohydro ER,1 which is formulated as a capsule. It was originally approved without abuse-deterrent properties, but a new formulation incorporating excipients that form a viscous gel when the capsules are crushed and dissolved has been approved and will be ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Extended-Release Hydrocodone (Hysingla ER) for Pain
Article code: 1468c
 Electronic, downloadable article - $25