The Medical Letter on Drugs and Therapeutics
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1479
Daclatasvir (Daklinza) for HCV Genotype 3 Infection
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The FDA has approved daclatasvir (Daklinza – BMS), an oral direct-acting antiviral drug, for use with sofosbuvir (Sovaldi)1 for treatment of chronic hepatitis C virus (HCV) genotype 3 infection. Daclatasvir is the first drug approved for this indication that does not require the addition of interferon or ribavirin. It is approved in Japan and Europe in combination with other drugs for treatment of HCV genotypes 1-4.

GENOTYPE 3 — HCV genotype 3 is responsible for <10% of HCV cases in the US. It is the predominant genotype in South Asian countries such as India and Pakistan and is responsible for >25% of HCV cases in Central Asia, Australasia, eastern Europe, and tropical Latin America.2 It has been associated with higher rates of steatosis, cirrhosis, and hepatocellular carcinoma than other HCV ... more      

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Title: Daclatasvir (Daklinza) for HCV Genotype 3 Infection
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