The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1490
ISSUE 1490
March 14, 2016
Safety of Testosterone Replacement Therapy
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March 14, 2016 (Issue: 1490)
Three coordinated double-blind, placebo-controlled
clinical trials have evaluated the efficacy of one year of
testosterone replacement therapy in improving sexual
function, physical function, and vitality in a total of
790 men ≥65 years old with moderately low serum
testosterone concentrations and symptoms suggesting
hypoandrogenism. Sexual function improved
modestly, and there appeared to be marginal benefits
in some areas of physical function and vitality as well.
The trials were not designed to evaluate the safety of
testosterone replacement therapy.
... more
- PJ Snyder et al. Effects of testosterone treatment in older men. N Engl J Med 2016; 374:611.
- JE Michaud et al. Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk. Ther Adv Urol 2015; 7:378.
- P Boyle et al. Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate specific antigen (PSA): a meta-analysis. BJU Int 2016 January 18 (epub).
- S Basaria et al. Adverse events associated with testosterone administration. N Engl J Med 2010; 363:109.
- L Xu et al. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med 2013; 11:108.
- G Corona et al. Cardiovascular risk associated with testosterone-boosting medications: a systematic review and metaanalysis. Expert Opin Drug Saf 2014; 13:1327.
- R Sharma et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J 2015; 36:2706.
- A Morgentaler et al. Testosterone therapy and cardiovascular risk: advances and controversies. Mayo Clin Proc 2015; 90:224.

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Title: Safety of Testosterone Replacement Therapy
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