The Medical Letter on Drugs and Therapeutics
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1492
Buprenorphine Buccal Film (Belbuca) for Chronic Pain
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Belbuca (Endo), a buccal formulation of the partial opioid agonist buprenorphine, has been approved by the FDA for management of pain severe enough to require daily, around-the-clock, long-term opioid treatment. Buprenorphine is also available as a transdermal patch (Butrans) and in a parenteral formulation (Buprenex, and generics) for treatment of pain. A sublingual formulation of buprenorphine and buccal and sublingual formulations containing buprenorphine and the opioid antagonist naloxone are approved for use as alternatives to methadone for treatment of opioid dependence.1,2

MECHANISM OF ACTION — Buprenorphine binds with high affinity to, and slowly dissociates from, the mu-opioid receptor. In the dosage range for which Belbuca is approved, buprenorphine produces typical opioid agonist effects. In higher doses, its agonist effects reach ... more      

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Title: Buprenorphine Buccal Film (Belbuca) for Chronic Pain
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