The Medical Letter on Drugs and Therapeutics
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1513
Drug Interaction: Dabigatran (Pradaxa) and Statins
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The results of a recently published study suggest that taking the oral direct thrombin inhibitor dabigatran etexilate (Pradaxa) with either simvastatin (Zocor, and others) or lovastatin (Altoprev, and others) increases the risk of major hemorrhage.1

POSSIBLE MECHANISMS — The mechanism for this potential interaction has not been established. Dabigatran etexilate is a substrate of the transporter P-glycoprotein (P-gp); drugs that inhibit P-gp could increase dabigatran serum concentrations and the risk of bleeding.2 In in vitro studies, simvastatin and lovastatin have been shown to inhibit P-gp3; however, limited data from in vivo studies suggest simvastatin and lovastatin have little to no effect on serum concentrations of P-gp substrates such as digoxin. ... more      

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Title: Drug Interaction: Dabigatran (Pradaxa) and Statins
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