The Medical Letter on Drugs and Therapeutics
Subscribers: Log in to read full issue.  Not a subscriber?  Subscribe or purchase issue.
Reduction of Cardiovascular Risk with Evolocumab (Repatha)

The results of the recently published FOURIER trial have shown a reduction in cardiovascular events with addition of the PCSK9 inhibitor evolocumab (Repatha) to statin therapy in patients with atherosclerotic cardiovascular disease (ASCVD).

EVOLOCUMAB — Evolocumab is a human IgG2 monoclonal antibody injected subcutaneously every two weeks or once monthly. It targets PCSK9 (proprotein convertase subtilisin kexin type 9) and prevents it from binding to LDL receptors, resulting in increased LDL receptor expression and increased hepatic uptake of LDL-cholesterol (LDL-C). Like alirocumab (Praluent), the other FDA-approved PCSK9 inhibitor, evolocumab has been found to reduce LDL-C levels by about 55-60% when added to statin therapy, and it is generally well tolerated.1 Alirocumab has not yet been shown to improve cardiovascular outcomes. ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this issue?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this issue:
Title: Issue 1519
 Downloadable, electronic issue - $45

Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian