The Medical Letter on Drugs and Therapeutics
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1519
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Reduction of Cardiovascular Risk with Evolocumab (Repatha)

The results of the recently published FOURIER trial have shown a reduction in cardiovascular events with addition of the PCSK9 inhibitor evolocumab (Repatha) to statin therapy in patients with atherosclerotic cardiovascular disease (ASCVD).

EVOLOCUMAB — Evolocumab is a human IgG2 monoclonal antibody injected subcutaneously every two weeks or once monthly. It targets PCSK9 (proprotein convertase subtilisin kexin type 9) and prevents it from binding to LDL receptors, resulting in increased LDL receptor expression and increased hepatic uptake of LDL-cholesterol (LDL-C). Like alirocumab (Praluent), the other FDA-approved PCSK9 inhibitor, evolocumab has been found to reduce LDL-C levels by about 55-60% when added to statin therapy, and it is generally well tolerated.1 Alirocumab has not yet been shown to improve cardiovascular outcomes. ... more      

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