The Medical Letter on Drugs and Therapeutics
Prasterone (Intrarosa) for Dyspareunia
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The FDA has approved the steroid prasterone (Intrarosa – Endoceutics) for intravaginal treatment of postmenopausal women with moderate-to-severe dyspareunia due to vulvovaginal atrophy (VVA). Also called dehydroepiandrosterone (DHEA), prasterone is produced in the adrenal glands, gonads, and brain and converted intracellularly into active metabolites of estrogens and androgens. DHEA has been available over the counter for years as an oral dietary supplement claimed to benefit sexual, cardiovascular, and neuropsychiatric dysfunction.1-3

TREATMENT OF DYSPAREUNIA — VVA is caused by lack of estrogen and is common among postmenopausal women. It can cause irritation, vaginal dryness, and pain with intercourse.4

Over-the-counter, nonhormonal, vaginal moisturizers and lubricants (Replens, K-Y, and others) may provide ... more       Show References Hide References

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Title: Prasterone (Intrarosa) for Dyspareunia
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