The Medical Letter on Drugs and Therapeutics
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia
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The FDA has approved Duzallo (Ironwood), a fixed-dose combination of the uric acid transporter 1 (URAT1) inhibitor lesinurad (Zurampic)1 and the xanthine oxidase inhibitor allopurinol (Zyloprim, and generics), for once-daily treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone.

STANDARD TREATMENT — Recent guidelines offer conflicting views on the benefits of monitoring serum uric acid levels and the appropriate use of urate-lowering therapy in patients with gout,2-4 but most expert clinicians still treat gout-associated hyperuricemia initially with a xanthine oxidase inhibitor such as allopurinol or febuxostat (Uloric) with the goal of reducing the serum uric acid level to <6.0 mg/dL (and preferably to <5.0 mg/dL). The ... more      

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Title: Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia
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