The Medical Letter on Drugs and Therapeutics
PARP Inhibitors for Ovarian Cancer
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

Three oral poly(ADP-ribose) polymerase (PARP) inhibitors have been approved by the FDA for treatment of advanced, recurrent ovarian cancer. Olaparib (Lynparza – AstraZeneca), niraparib (Zejula – Tesaro), and rucaparib (Rubraca – Clovis) are each approved for somewhat different indications and for patients with different biomarkers (see Table 2).

MECHANISM OF ACTION — PARPs are involved in many cellular functions, including DNA transcription and repair of single-strand breaks. PARP inhibition leads to double-strand DNA breaks that activate homologous recombination (HR) repair, but when HR is defective, as it is in patients with BRCA mutations, an error-prone repair mechanism is activated that is unable to accurately repair these breaks, leading to DNA damage, apoptosis, and cell death (synthetic lethality). PARP inhibitors are cytotoxic for cancer ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: PARP Inhibitors for Ovarian Cancer
Article code: 1535d
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian