The Medical Letter on Drugs and Therapeutics
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Drugs for Postmenopausal Osteoporosis
Superseded by The Medical Letter "Drugs for Postmenopausal Osteoporosis" - Issue 1602, July 13, 2020
Diagnosis of osteoporosis is based on the results of bone mineral density (BMD) testing or by the occurrence of a fragility fracture. Bone densitometry results are generally reported in terms of standard deviations (SD) from the mean value for young adults (T-score). The World Health Organization (WHO) defines osteoporosis in women as a T-score of -2.5 or below in the spine, femoral neck, or total hip. A computerized model (FRAX) is available that estimates the 10-year probability of a hip fracture or other major osteoporotic fracture based on clinical risk factors and BMD at the femoral neck.
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